VIP

Neuroendocrine Signaling & Vascular Homeostasis Research Compound

Product Overview

VIP (Vasoactive Intestinal Peptide) is a 28-amino acid neuropeptide that serves as a potent endogenous ligand for the VPAC1 and VPAC2 receptors. By activating cAMP-dependent signaling cascades, it facilitates the study of smooth muscle relaxation, vasodilation, and immune system modulation in preclinical settings. This neuropeptide is a foundational tool for researchers investigating the complex interactions within neuroendocrine signaling and peptide-mediated vascular homeostasis.

Key Research Applications

• Neuroendocrine Signaling: Utilized to map the pathways and regulatory functions of neuropeptides within the endocrine and nervous systems.

• Vascular Homeostasis: Targeted in research exploring the mechanisms of vasodilation and the maintenance of blood flow.

• Inflammatory Regulation: Frequently used to investigate the peptide’s role in immune modulation and the control of inflammatory responses.

• Smooth Muscle Relaxation: Serves as a primary model for studying cAMP-mediated relaxation of non-vascular smooth muscle tissues.

• VPAC Receptor Studies: Evaluated for its high-affinity binding and activation of VPAC1 and VPAC2 receptor subtypes.

Why Researchers Choose VIP

• High Biological Fidelity: Functions as a potent endogenous ligand, providing a highly relevant model for human physiological signaling.

• Verified Analytical Purity: Synthesized to a verified 99% HPLC purity, ensuring consistent and reproducible experimental results.

• Stability-Focused Format: Arrives in a lyophilized (powder) form to maintain maximum stability and potency during laboratory handling and storage.

Technical Specifications

• Molecular Formula: C147​_H237_​N43_​O43​S

• Molecular Weight: 3326.8 g/mol

• CAS Number: 37221-79-7

• Sequence: (28 amino acid neuropeptide sequence)

• Monoisotopic Mass: 3324.7401145

Research Notice: VIP 6mg is strictly for laboratory and scientific research use only. It is not approved for human or animal consumption, medical treatment, or therapeutic use.

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Validated Synthesis & Expedited Fulfillment

Clinical-Grade Synthesis & Purity

Our RUO peptides are engineered via precision synthesis, utilizing meticulously validated protocols to ensure uncompromising accuracy and batch-to-batch consistency. To maintain verified purity, every production lot undergoes independent third-party analysis—including HPLC and mass spectrometry—to confirm molecular identity and a purity of >99%. For expedited research timelines, we provide same-day fulfillment from our U.S. facility for orders placed before 12 PM PST, ensuring rapid and reliable delivery.

References:

1. Gozes I et al., Front Endocrinol (Lausanne), 2017 8:282

2. Laburthe M et al., Biochim Biophys Acta, 2007 1768(4):955–972

3. Delgado M et al., Trends Mol Med, 2004 10(4):201–208