KPV

KPV (Ac-KPV-NH2)

Alpha-MSH Derivative & Inflammatory Signaling Research Compound

Product Overview

KPV (Ac-KPV-NH2) is a synthetic tripeptide (Lys–Pro–Val) that represents the C-terminal fragment of alpha-melanocyte-stimulating hormone (α-MSH). In laboratory environments, it is utilized as a chemically defined tool to explore inflammatory signaling networks, epithelial transport biology, and transcriptional regulation within cell-based systems and animal models. This peptide is specifically evaluated for its ability to modulate cytokine balance and immune-mediated stress responses under controlled preclinical conditions.

Key Research Applications

• Intestinal Inflammation Modeling: Used in experimental workflows to quantify tissue inflammatory markers and cytokine-associated signaling.

• Epithelial Integrity Studies: Targeted in research exploring PepT1-mediated uptake and the maintenance of mucosal barrier integrity.

• Transcriptional Regulation: Frequently utilized to measure NF-κB and MAPK pathway activity endpoints under inflammatory stimulation.

• Matrix Remodeling Research: Evaluated in wound repair models to examine cytokine-regulated fibroblast signaling and collagen-related endpoints.

• Antimicrobial Assays: Employed to assess peptide-microbe interactions and structure-activity relationships in controlled culture systems.

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Why Researchers Choose KPV (Ac-KPV-NH2)

• Mechanistic Specificity: Acts through both melanocortin receptor-dependent and receptor-independent pathways to regulate inflammatory mediators.

• High Analytical Purity: Synthesized to a verified 99% HPLC purity, ensuring accuracy and reproducibility in sensitive biochemical assays.

• Stability-Focused Format: Arrives in a lyophilized (powder) form to maximize stability and structural integrity during laboratory handling and storage.

• Uptake Compatibility: Demonstrated cellular entry via the PepT1 transporter, which is often upregulated in inflammatory tissue paradigms.

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Technical Specifications

Amino Acid Sequence: Lys-Pro-Val

Molecular Formula: C17_H32_N6_O4

Molecular Weight: 384.48 g/mol

CAS Number: 112965-21-6

Purity: 99% HPLC

Research Notice: KPV is strictly for laboratory and scientific research use only. It is not approved for human or animal consumption, medical treatment, or therapeutic use.

Validated Synthesis & Expedited Fulfillment

Clinical-Grade Synthesis & Purity

Our RUO peptides are engineered via precision synthesis, following meticulously validated protocols to ensure batch-to-batch consistency and uncompromising accuracy. To maintain verified purity, every production lot undergoes independent analytical testing—including HPLC and mass spectrometry—to confirm molecular identity and a purity level of 99%. For expedited research timelines, we provide same-day fulfillment from our facility for orders placed before 12 PM PST.

References:

1. Getting SJ et al., J Immunol, 1999 163(10):5959–5967

2. Lipton JM et al., Ann NY Acad Sci, 2009 1170:123–130

3. Grieco P et al., Peptides, 2013 44:111–115