CJC-1295 w/DAC

CJC-1295 w/DAC

Growth Hormone Secretagogue & Sustained Signaling Research Compound

Product Overview

CJC-1295 with DAC (Drug Affinity Complex) is a synthetic analog of Growth Hormone-Releasing Hormone (GHRH). In laboratory settings, it is utilized as a chemically defined tool to investigate the stimulation of the pituitary gland and the subsequent pulsatile release of endogenous growth hormone. This peptide is highly regarded in preclinical research for its integration of DAC technology, which significantly extends its half-life by allowing the compound to bind to circulating albumin, making it a primary subject for studying sustained metabolic signaling.

Key Research Applications

• Pituitary Axis Modeling: Used in experimental workflows to study the activation of GHRH receptors and the regulation of the Growth Hormone/IGF-1 axis.

• Extended Half-Life Studies: Targeted in research exploring the efficacy of Drug Affinity Complex (DAC) in maintaining therapeutic plasma levels and resisting enzymatic degradation.

• Metabolic Signaling Research: Utilized to quantify the impact of sustained GH elevation on lipid metabolism, protein synthesis, and glucose homeostasis.

• Cellular Repair & Hypertrophy: Frequently employed to measure the peptide’s role in investigating musculoskeletal recovery and the modulation of lean tissue mass in specialized models.

• Long-Term Hormonal Regulation: Evaluated for its impact on the stability of hormonal output over extended observational periods compared to non-DAC analogs.

Why Researchers Choose CJC-1295 with DAC

• Superior Pharmacokinetic Profile: The addition of DAC provides a significantly extended half-life (up to 8 days in some models), allowing for infrequent administration in long-term assays.

• High Analytical Purity: Synthesized to a verified 99% HPLC purity, ensuring maximum accuracy and reproducibility in sensitive laboratory environments.

• Stability-Focused Format: Arrives in a lyophilized (powder) form to maintain structural integrity and maximize shelf life during laboratory handling.

• Reliable GHRH Mimetic: Provides a consistent and potent subject for investigating neuropeptide-driven endocrine responses without the rapid clearance of natural GHRH.

Technical Specifications

• Amino Acid Sequence: [Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2 + DAC]

• Molecular Formula:  C165_H271_N47_O46

• Molecular Weight: 3649.3 g/mol

• CAS Number: 863288-34-0

• Purity: 99% HPLC

• Research Notice: CJC-1295 with DAC is strictly for laboratory and scientific research use only. It is not approved for human or animal consumption, medical treatment, or therapeutic use.

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Validated Synthesis & Expedited Fulfillment

Clinical-Grade Synthesis & Purity

Our RUO peptides are engineered via precision synthesis, following meticulously validated protocols to ensure batch-to-batch consistency and uncompromising accuracy. To maintain verified purity, every production lot undergoes independent analytical testing—including HPLC and mass spectrometry—to confirm molecular identity and a purity level of 99%. For expedited research timelines, we provide same-day fulfillment from our facility for orders placed before 12 PM PST.

References:

• Teichman SL et al., J Clin Endocrinol Metab, 2006;91(3):799–805

• Jette L et al., Endocrinology, 2005;146(7):3052–3058

• Ionescu M et al., J Clin Endocrinol Metab, 2006;91(12):4792–4797

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Storage & Handling Guide

To ensure the long-term stability and reproducibility of your experimental results, please follow these standardized laboratory protocols for CJC-1295 with DAC:

I. Long-Term Storage (Lyophilized Powder)

• Temperature: Store at -20°C for long-term stability. The lyophilized format is stable at room temperature for short-term transit but should be frozen upon arrival.

• Environment: Keep in a cool, dry place away from direct light. Ensure the vial remains tightly sealed to prevent moisture absorption (hygroscopy).

II. Reconstitution Protocol

• Solubility: Allow peptide and water to come up to room temperature. CJC-1295 with DAC is soluble in sterile water or bacteriostatic water. Gently swirl the vial to dissolve the powder; do not shake, as agitation can damage the peptide structure.

III. Storage of Reconstituted Solution

• Short-Term: Once reconstituted, the solution should be stored at 2°C to 8°C and used within 7 days.

• Long-Term: For extended use, aliquot the solution into single-use volumes and store at -20°C or -80°C.

• Avoid Freeze-Thaw Cycles: Repeated freezing and thawing significantly degrade peptide structure. Always use fresh aliquots for each assay.

Research Use Only: This compound is intended for in vitro laboratory research and animal imaging studies. It is not for human or clinical use.