FOXO4-DRI

FOXO4-DRI (Proxofim)

Synthetic D-Retro-Inverso Peptide & Senolytic Research Compound

Product Overview

FOXO4-DRI 10mg is a synthetic D-retro-inverso peptide engineered to selectively interrupt the interaction between FOXO4 and the p53 tumor suppressor protein. By utilizing D-amino acids, this compound is designed for superior biological stability compared to standard L-amino acid sequences. In laboratory settings, FOXO4-DRI is used to investigate the clearance of senescent cells, providing researchers with a tool to explore cellular longevity and apoptotic signaling pathways.

Key Research Applications

• Senolytic Mechanism Studies: Valued for its ability to selectively induce apoptosis in senescent cells by disrupting FOXO4-p53 nuclear retention.

• Cellular Longevity Research: Targeted in studies exploring the impact of removing “zombie” cells on tissue rejuvenation and overall lifespan in experimental models.

• DNA Damage Response (DDR): Frequently utilized to observe how cells handle persistent DNA damage and the signaling transitions between senescence and programmed cell death.

• Selective Apoptosis Induction: Evaluated for its capacity to trigger death in senescent phenotypes while leaving healthy, non-senescent cells unaffected.

Why Researchers Choose FOXO4-DRI

• D-Retro-Inverso Design: The inverted sequence of D-amino acids provides significant resistance to enzymatic degradation, extending its half-life during experimental procedures.

• High Analytical Purity: Synthesized to a verified 99% HPLC purity, ensuring high-fidelity results in demanding senolytic research.

• Targeted Specificity: Designed with a specific mechanism of action that allows for the precise study of p53-mediated cell death in aging research.

Technical Specifications

• Molecular Formula:  C228_H388_N86_O64

• Molecular Weight: ~5358.05 g/mol

• Structure: 16-amino acid D-retro-inverso sequence

• Format: Lyophilized powder for maximum laboratory stability

Research Notice: FOXO4-DRI 10mg is strictly for laboratory and scientific research use only. It is not approved for human or animal consumption, medical treatment, or therapeutic use.

---

Validated Synthesis & Expedited Fulfillment

Clinical-Grade Synthesis & Purity

Our RUO peptides are engineered via precision synthesis, utilizing meticulously validated protocols to ensure uncompromising accuracy and batch-to-batch consistency. To maintain verified purity, every production lot undergoes independent third-party analysis—including HPLC and mass spectrometry—to confirm molecular identity and a purity of >99%. For expedited research timelines, we provide same-day fulfillment from our U.S. facility for orders placed and paid before 12 PM PST, ensuring rapid and reliable delivery.

References:

1. Kirkland JL et al., J Clin Invest, 2017;127(4):1247–1256

2. Yosef R et al., Aging (Albany NY), 2017;9(8):1758–1777

3. de Keizer PLJ, Trends Mol Med, 2017;23(9):751–762