NAD+

NAD+

Essential Cellular Coenzyme & Metabolic Research Compound

Product Overview

NAD+ (nicotinamide adenine dinucleotide) is a fundamental cellular coenzyme required for redox metabolism and biological energy production in all living organisms. It acts as a vital electron carrier, transitioning between its oxidized (NAD+) and reduced (NADH) forms to facilitate mitochondrial oxidative phosphorylation and glycolytic energy transfer in experimental settings. Beyond metabolic functions, NAD+ is a mandatory substrate for sirtuins and poly(ADP-ribose) polymerases (PARPs), which regulate critical pathways like DNA repair and cellular stress responses.

Key Research Applications

• Mitochondrial Homeostasis: Valued for its role in investigating the efficiency of the electron transport chain and oxidative phosphorylation.

• Sirtuin & PARP Activation: Targeted in studies exploring DNA repair mechanisms, gene expression regulation, and cellular longevity.

• Metabolic Research: Specifically utilized to examine muscle metabolism and glycolytic energy transfer.

• Neuroprotection Studies: Frequently used in preclinical models to explore mechanisms of neuronal resilience and protection against cellular stress.

• Longevity & Aging Models: Evaluated for its influence on molecular pathways associated with aging and overall cellular resilience.

Why Researchers Choose NAD+

• Dual Metabolic Role: Essential for both energy production (as an electron carrier) and signaling (as an enzyme substrate).

• High Analytical Purity: Available at 99% purity and verified via HPLC to ensure reliable and reproducible data.

• Critical Signaling Substrate: Provides a direct way to study the activation of sirtuins and other NAD+-dependent enzymes.

Technical Specifications

• Molecular Formula:  C21_H28_N7_O14_P2

• Molecular Weight: ~664.4 Da

• CAS Number: 53-84-9

• Form: Lyophilized powder for maximum stability

Research Notice: NAD+ is strictly for laboratory and scientific research use only. It is not approved for human or animal consumption, medical treatment, or therapeutic use.

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Validated Synthesis & Expedited Fulfillment

Clinical-Grade Synthesis & Purity

Our RUO peptides are engineered via precision synthesis, utilizing meticulously validated protocols to ensure uncompromising accuracy and batch-to-batch consistency. To maintain verified purity, every production lot undergoes independent third-party analysis—including HPLC and mass spectrometry—to confirm molecular identity and a purity of >99%. For expedited research timelines, we provide same-day fulfillment from our U.S. facility for orders placed before 12 PM PST, ensuring rapid and reliable delivery.

References:

1. Cantó C et al., Cell Metab, 2015 22(1):31–53

2. Verdin E, Science, 2015 350(6265):1208–1213

3. Yoshino J et al., Cell Metab, 2018 27(3):529–547