MOTS-C

MOTS-C

Mitochondrial-Derived Heptadecapeptide & Metabolic Signaling Compound

Product Overview

MOTS-c is a specialized research peptide originating from the mitochondria, consisting of a 16-amino acid sequence (Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg). Uniquely encoded within the mitochondrial 12S rRNA gene, this compound is primarily studied for its role in regulating cellular metabolism via the activation of the AMPK pathway. In preclinical models, MOTS-c serves as a critical tool for investigating mitochondrial homeostasis and systemic energy balance.

Key Research Applications

• Metabolic Regulation: Heavily utilized in studies focused on AMPK activation and its influence on cellular glucose and lipid metabolism.

• Mitochondrial Homeostasis: Targeted in research exploring how mitochondrial-derived peptides maintain organelle health and function.

• Aging & Longevity Research: Frequently used as a model to study the decline of mitochondrial signaling and energy regulation over time.

• Stress Adaptation: Evaluated for its ability to help cells adapt to metabolic stress and maintain homeostasis under challenging conditions.

• Inter-Organellar Communication: Serves as a primary tool for exploring signaling mechanisms between the mitochondria and the cell nucleus.

Why Researchers Choose MOTS-c

• Unique Genetic Origin: One of the few known peptides encoded directly within the mitochondrial genome rather than the nuclear genome.

• High Analytical Purity: Our MOTS-c is synthesized to a verified purity of 99% HPLC, ensuring consistent and reproducible experimental data.

• Well-Characterized Mechanism: Backed by significant preclinical data regarding its metabolic and signaling effects in laboratory models.

Technical Specifications

• Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg

• Molecular Formula:  C101_H152_N28_O22_S2

• Molecular Weight: 2174.6 g/mol

• CAS Number: 1627580-64-6

Research Notice: MOTS-c is strictly for laboratory and scientific research use only. It is not approved for human or animal consumption, medical treatment, or therapeutic use.

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Validated Synthesis & Expedited Fulfillment

Clinical-Grade Synthesis & Purity

Our RUO peptides are engineered via precision synthesis, utilizing meticulously validated protocols to ensure uncompromising accuracy and batch-to-batch consistency. To maintain verified purity, every production lot undergoes independent third-party analysis—including HPLC and mass spectrometry—to confirm molecular identity and a purity of >99%. For expedited research timelines, we provide same-day fulfillment from our U.S. facility for orders placed before 12 PM PST, ensuring rapid and reliable delivery.

References:

1. Lee C et al., Cell Metab, 2015;21(3):443–454

2. Kim KH et al., Nat Commun, 2018;9(1):4774

3. Lee C et al., Cell Metab, 2016;23(2):303–309