DERMORPHIN

DERMORPHIN

Selective Mu-Opioid Receptor Agonist & Neuropeptide Signaling Research Compound

Product Overview

Dermorphin is a natural heptapeptide first isolated from the skin of South American frogs (Phyllomedusa genus). In laboratory settings, it is utilized as a chemically defined tool to investigate the high-affinity activation of mu-opioid receptors (MOR). This peptide is highly regarded in preclinical research for its extreme potency—significantly exceeding that of morphine—and its role in exploring neuro-signaling, antinociceptive pathways, and the modulation of endocrine responses in the central nervous system.

Key Research Applications

• Mu-Opioid Receptor (MOR) Profiling: Used in experimental workflows to study the selective binding and activation of MOR over delta or kappa opioid receptor subtypes.

• Antinociceptive Pathway Research: Targeted in studies exploring the mechanisms of pain signaling and the development of high-potency analgesia models.

• Neuroendocrine Modulation: Utilized to quantify the impact of opioid peptide signaling on the release of pituitary hormones and hypothalamic activity.

• G-Protein Coupled Receptor (GPCR) Signaling: Frequently employed to measure the efficiency of signal transduction following peptide-receptor interaction.

• Behavioral Pharmacology Studies: Evaluated for its effects on motor activity and physiological arousal in specialized animal models.

Why Researchers Choose Dermorphin

• Exceptional Binding Affinity: Demonstrates intense selectivity and potency at the mu-opioid receptor, providing a high-fidelity subject for opioid research.

• High Analytical Purity: Synthesized to a verified 99% HPLC purity, ensuring maximum accuracy and reproducibility in sensitive laboratory assays.

• Stability-Focused Format: Arrives in a lyophilized (powder) form to maintain structural integrity and maximize shelf life during laboratory handling.

• Unique Evolutionary Subject: Offers a precise molecular template for studying D-amino acid containing peptides and their resistance to enzymatic degradation.

Technical Specifications

• Amino Acid Sequence: Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2

• Molecular Formula:  C40_H50_N8_O10

• Molecular Weight: 802.9 g/mol

• CAS Number: 77614-16-5

• Purity: 99% HPLC

• Research Notice: Dermorphin is strictly for laboratory and scientific research use only. It is not approved for human or animal consumption, medical treatment, or therapeutic use.

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Validated Synthesis & Expedited Fulfillment

Clinical-Grade Synthesis & Purity

Our RUO peptides are engineered via precision synthesis, following meticulously validated protocols to ensure batch-to-batch consistency and uncompromising accuracy. To maintain verified purity, every production lot undergoes independent analytical testing—including HPLC and mass spectrometry—to confirm molecular identity and a purity level of 99%. For expedited research timelines, we provide same-day fulfillment from our facility for orders placed before 12 PM PST.

References:

• Montecucchi PC et al., Int J Pept Protein Res, 1981;17(3):275–283

• Broccardo M et al., Br J Pharmacol, 1981;73(3):625–631

• Melchiorri P et al., Gen Pharmacol, 1996;27(7):1099–1107

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Storage & Handling Guide

To ensure the long-term stability and reproducibility of your experimental results, please follow these standardized laboratory protocols for Dermorphin:

I. Long-Term Storage (Lyophilized Powder)

• Temperature: Store at -20°C for long-term stability. The lyophilized format is stable at room temperature for short-term transit but should be frozen upon arrival.

• Environment: Keep in a cool, dry place away from direct light. Ensure the vial remains tightly sealed to prevent moisture absorption (hygroscopy).

II. Reconstitution Protocol

• Solubility: Dermorphin is soluble in sterile water or bacteriostatic water. Gently swirl the vial to dissolve; do not shake vigorously.

III. Storage of Reconstituted Solution

• Short-Term: Once reconstituted, the solution should be stored at 2°C to 8°C and used within 7 days.

• Long-Term: For extended use, aliquot the solution into single-use volumes and store at -20°C or -80°C.

• Avoid Freeze-Thaw Cycles: Repeated freezing and thawing significantly degrade peptide structure. Always use fresh aliquots for each assay.

Research Use Only: This compound is intended for in vitro laboratory research and animal imaging studies. It is not for human or clinical use.