MELANOTAN-1

MELANOTAN-1

Selective Melanocortin Receptor Agonist & Photobiology Research Compound

Product Overview

Melanotan 1 (Afamelanotide) is a synthetic tridecapeptide and a non-selective agonist of the melanocortin receptors (primarily MC1R). It is a structural analog of the naturally occurring alpha-melanocyte stimulating hormone.  In laboratory settings, it is utilized as a chemically defined tool to explore melanogenesis, protective photobiology, and the modulation of skin pigmentation pathways. This peptide is highly regarded in preclinical research for its role in investigating cellular responses to ultraviolet (UV) radiation and the signaling mechanisms of the neuroendocrine system.

Key Research Applications

• Melanogenesis Pathway Modeling: Used in experimental workflows to study the stimulation of melanin production and the activation of the MC1R receptor.

• Photoprotection Research: Targeted in studies exploring the protection of skin cells from oxidative stress and DNA damage induced by UV radiation.

• Neuroendocrine Signaling Studies: Utilized to quantify the interaction of melanocortin analogs with central and peripheral regulatory systems.

• Cytoprotective Pathway Analysis: Frequently employed to measure the peptide’s impact on anti-inflammatory responses and cellular recovery in specialized animal models.

• Dermal Barrier Integrity: Evaluated for its impact on epidermal structural stability and its role in modulating the cutaneous response to environmental stressors.

Why Researchers Choose Melanotan 1

• High Potency & Stability: Engineered to have a longer half-life and greater potency than endogenous A-MSH, providing a more robust subject for physiological research.

• High Analytical Purity: Synthesized to a verified 99% HPLC purity, ensuring maximum accuracy and reproducibility in sensitive laboratory assays.

• Stability-Focused Format: Arrives in a lyophilized (powder) form to maintain structural integrity and maximize shelf life during laboratory handling.

• Extensive Investigative Background: Benefit from a compound with a well-documented history in clinical and preclinical paradigms regarding dermal photobiology.

Technical Specifications

• Amino Acid Sequence: [Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2]

• Molecular Formula:  C78_H111_N21_O19

• Molecular Weight: 1646.85 g/mol

• CAS Number: 75921-69-6

• Purity: 99% HPLC

• Research Notice: Melanotan 1 is strictly for laboratory and scientific research use only. It is not approved for human or animal consumption, medical treatment, or therapeutic use.

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Validated Synthesis & Expedited Fulfillment

Clinical-Grade Synthesis & Purity

Our RUO peptides are engineered via precision synthesis, following meticulously validated protocols to ensure batch-to-batch consistency and uncompromising accuracy. To maintain verified purity, every production lot undergoes independent analytical testing—including HPLC and mass spectrometry—to confirm molecular identity and a purity level of 99%. For expedited research timelines, we provide same-day fulfillment from our facility for orders placed before 12 PM PST.

References:

• Hadley ME et al., Ann N Y Acad Sci, 1993;680:424–439

• Abdel-Malek ZA et al., Photochem Photobiol, 2006;82(6):1534–1543

• Dorr RT et al., Arch Dermatol, 2004;140(7):827–835

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Storage & Handling Guide

To ensure the long-term stability and reproducibility of your experimental results, please follow these standardized laboratory protocols for Melanotan 1:

I. Long-Term Storage (Lyophilized Powder)

• Temperature: Store at -20°C for long-term stability. The lyophilized format is stable at room temperature for short-term transit but should be frozen upon arrival.

• Environment: Keep in a cool, dry place away from direct light. Ensure the vial remains tightly sealed to prevent moisture absorption (hygroscopy).

II. Reconstitution Protocol

• Solubility: Melanotan 1 is soluble in sterile water or bacteriostatic water. Gently swirl the vial; avoid vigorous agitation to prevent peptide degradation.

III. Storage of Reconstituted Solution

• Short-Term: Once reconstituted, the solution should be stored at 2°C to 8°C and used within 7 days.

• Long-Term: For extended use, aliquot the solution into single-use volumes and store at -20°C or -80°C.

• Avoid Freeze-Thaw Cycles: Repeated freezing and thawing significantly degrade peptide structure. Always use fresh aliquots for each assay.

Research Use Only: This compound is intended for in vitro laboratory research and animal imaging studies. It is not for human or clinical use.