SLU-PP-332

SLU-PP-332

PPARδ Agonist & Metabolic Signaling Research Compound

Product Overview

SLU-PP-332 is a potent, small-molecule research compound classified as a selective agonist of the peroxisome proliferator-activated receptor delta (PPARδ). In laboratory settings, it is utilized as a precision tool to investigate the transcriptional regulation of skeletal muscle metabolism. SLU-PP-332 is highly regarded in preclinical research for its ability to mimic the effects of aerobic exercise by enhancing oxidative capacity and mitochondrial function without physical exertion.

Key Research Applications

• Mitochondrial Biogenesis Modeling: Used in experimental workflows to study the upregulation of genes responsible for mitochondrial expansion and cellular energy production.

• Fatty Acid Oxidation Research: Targeted in studies exploring the shift in cellular substrate preference toward lipid utilization and metabolic efficiency.

• Endurance Signaling Pathways: Utilized to quantify the impact of PPARδ activation on “marathon-like” muscle fiber transformation in specialized animal models.

• Metabolic Syndrome Regulation: Frequently employed to measure the compound’s interaction with glucose homeostasis and lipid profile modulation under high-stress dietary conditions.

• Muscle Fiber Plasticity: Evaluated for its role in promoting the transition from glycolytic to oxidative muscle fibers in research environments.

Why Researchers Choose SLU-PP-332

• High Receptor Selectivity: Demonstrates a high affinity for the delta isoform of the PPAR family, providing a high-fidelity subject for isolating metabolic pathways.

• High Analytical Purity: Synthesized to a verified 99% HPLC purity, ensuring maximum accuracy and reproducibility in sensitive laboratory assays.

• Stability-Focused Format: Arrives in a lyophilized (powder) form to maintain structural integrity and maximize shelf life during laboratory handling.

• Physiological Synergy: Provides a unique subject for investigating the intersection of chemical signaling and physiological performance markers.

Technical Specifications

• Molecular Formula: C18_H14_N2_O2

• Molecular Weight: 290.3 g/mol

• CAS Number: 303760-60-3

• Purity: 99% HPLC

• Research Notice: SLU-PP-332 is strictly for laboratory and scientific research use only. It is not approved for human or animal consumption, medical treatment, or therapeutic use.

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Validated Synthesis & Expedited Fulfillment

Clinical-Grade Synthesis & Purity

Our RUO compounds are engineered via precision synthesis, following meticulously validated protocols to ensure batch-to-batch consistency and uncompromising accuracy. To maintain verified purity, every production lot undergoes independent analytical testing—including HPLC and mass spectrometry—to confirm molecular identity and a purity level of 99%. For expedited research timelines, we provide same-day fulfillment from our facility for orders placed before 12 PM PST.

References:

• Narkar VA et al., Cell, 2008;134(3):405–415

• Fan W et al., J Biol Chem, 2004;279(7):5241–5248

• Billon C et al., Cell Metab, 2022;34(1):69–84

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Storage & Handling Guide

To ensure the long-term stability and reproducibility of your experimental results, please follow these standardized laboratory protocols for SLU-PP-332:

I. Long-Term Storage (Lyophilized Powder)

• Temperature: Store at -20°C for long-term stability. The lyophilized format is stable at room temperature for short-term transit but should be frozen upon arrival.

• Environment: Keep in a cool, dry place away from direct light. Ensure the vial remains tightly sealed to prevent moisture absorption (hygroscopy).

II. Reconstitution Protocol

• Solubility: SLU-PP-332 is typically soluble in organic solvents such as DMSO or Ethanol. Researchers should select solvent systems appropriate for small-molecule agonists and compatible with their specific assays.

III. Storage of Reconstituted Solution

• Short-Term: Once reconstituted, the solution should be stored at 2°C to 8°C and used within 7 days.

• Long-Term: For extended use, aliquot the solution into single-use volumes and store at -20°C or -80°C.

• Avoid Freeze-Thaw Cycles: Repeated freezing and thawing significantly degrade molecular integrity. Always use fresh aliquots for each assay.

Note on Capsules: Any capsules provided are exclusively as inert containers for the dry transport and storage of research materials. They are not intended for ingestion or administration.

Research Use Only: This compound is intended for in vitro laboratory research and animal imaging studies. It is not for human or clinical use.