MELANOTAN-2

Melanotan-2 (MT2)

Nonselective Melanocortin Receptor Agonist & Neuroendocrine Signaling Research Compound

Product Overview

Melanotan 2 (MT2) is a synthetic cyclic heptapeptide (Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂) that functions as a potent nonselective melanocortin receptor agonist. In laboratory environments, it is utilized as a chemically defined tool to explore receptor binding and signal transduction across the MC1R–MC5R receptor subtypes. This peptide provides a specialized research model for investigating GPCR desensitization mechanisms, cAMP activation, and complex neuroendocrine signaling dynamics.

Key Research Applications

• Receptor Pharmacology Modeling: Used in experimental workflows to quantify binding affinity and potency across the melanocortin receptor family (MC1R-MC5R).

• Signal Transduction Studies: Targeted in research exploring G-protein coupled receptor (GPCR) activation and downstream cAMP signaling pathways.

• GPCR Desensitization Research: Utilized to observe the molecular mechanisms involved in receptor internalization and diminished response under prolonged stimulation.

• Neuroendocrine Signaling Dynamics: Frequently employed to measure the peptide’s influence on central and peripheral endocrine pathways.

• Melanogenesis Assays: Evaluated in specialized cell-based systems to study the pathways governing pigment-related signaling.

Why Researchers Choose Melanotan 2 (MT2)

• Broad Receptor Affinity: Acts as a versatile ligand for exploring the entire spectrum of melanocortin receptors.

• High Analytical Purity: Synthesized to a verified 99% HPLC purity, ensuring maximum accuracy and data reproducibility in sensitive biochemical assays.

• Stability-Focused Format: Arrives in a lyophilized (powder) form to maintain structural integrity and maximize stability during laboratory storage and reconstitution.

• Validated Chemical Structure: Features a cyclic architecture designed for enhanced stability and specific receptor interaction profiles in research models.

Technical Specifications

• Amino Acid Sequence: Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂

• Molecular Formula: C50_H69_N15_O9

• Molecular Weight: 1024.2 g/mol

• CAS Number: 121062-08-6

• Purity: 99% HPLC

• Research Notice: Melanotan 2 is strictly for laboratory and scientific research use only. It is not approved for human or animal consumption, medical treatment, or therapeutic use.

Validated Synthesis & Expedited Fulfillment

Clinical-Grade Synthesis & Purity

Our RUO peptides are engineered via precision synthesis, following meticulously validated protocols to ensure batch-to-batch consistency and uncompromising accuracy. To maintain verified purity, every production lot undergoes independent analytical testing—including HPLC and mass spectrometry—to confirm molecular identity and a purity level of 99%. For expedited research timelines, we provide same-day fulfillment from our facility for orders placed before 12 PM PST.

References:

• Hadley ME et al., Peptides, 1996 17(4):593–596

• Mountjoy KG et al., Endocr Rev, 1994 15(2):135–155

• Hruby VJ et al., Peptides, 2000 21(3):423–438

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Chemical Properties: Melanotan 2 (MT2)

Property	Specification
Full Chemical Name	Melanotan II
PubChem CID	92432
Molecular Formula	C50_H69_N15_O9
Molecular Weight	1024.2 g/mol
Hydrogen Bond Donor Count	13
Hydrogen Bond Acceptor Count	11
Purity (HPLC)	>99.0%
Physical Appearance	Lyophilized White Powder

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Storage & Handling Guide

To ensure the long-term stability and reproducibility of your experimental results, please follow these standardized laboratory protocols for Melanotan 2:

I. Long-Term Storage (Lyophilized Powder)

• Temperature: Store at -20°C for long-term stability. The lyophilized format is stable at room temperature for short-term transit but should be frozen upon arrival.

• Environment: Keep in a cool, dry place away from direct light. Ensure the vial remains tightly sealed to prevent moisture absorption (hygroscopy).

II. Reconstitution Protocol

• Solubility: Melanotan 2 is soluble in sterile water or bacteriostatic water.

• Procedure: Gently add the diluent to the vial. Do not shake the vial vigorously, as this can cause peptide denaturation. Instead, swirl the vial gently until the powder is fully dissolved.

III. Storage of Reconstituted Solution

• Short-Term: Once reconstituted, the solution should be stored at 2°C to 8°C and used within 7 days.

• Long-Term: For extended use, aliquot the solution into single-use volumes and store at -20°C or -80°C.

• Avoid Freeze-Thaw Cycles: Repeated freezing and thawing significantly degrade peptide structure. Always use fresh aliquots for each assay.

Research Use Only: This compound is intended for in vitro laboratory research and animal imaging studies. It is not for human or clinical use.