TB-500

TB-500 (Thymosin Beta-4) (43aa)

Actin-Binding Protein & Regenerative Signaling Research Compound

Product Overview

TB-500 (Thymosin Beta-4) is a synthetic research peptide consisting of a 43-amino acid sequence that mirrors the endogenous protein Thymosin Beta-4. This compound is recognized for its role as an actin-binding protein, playing a critical part in cytoskeletal organization and tissue repair processes. In preclinical environments, it is utilized as a chemically defined tool to explore the modulation of the $\beta$-actin/G-actin cycle, growth factor signaling, and the mechanisms of cellular motility.

Key Research Applications

• Cellular Migration Modeling: Used in experimental workflows to investigate how peptides regulate the movement of cells toward areas of physiological stress.

• Angiogenic Signaling Research: Targeted in studies exploring the stimulation of new blood vessel formation and vascular growth factor pathways.

• Cytoskeletal Organization Studies: Utilized to quantify the effects of actin polymerization on structural integrity and cellular dynamics.

• Wound Repair Research: Frequently employed as a model compound to examine peptide-mediated signaling in regenerative tissue environments.

• Growth Factor Modulation: Evaluated for its ability to interact with and influence signaling networks involved in tissue-level repair.

Why Researchers Choose TB-500 (Thymosin Beta-4)

• High Biological Fidelity: Directly corresponds to the 43-amino acid sequence of the naturally occurring protein for accurate physiological modeling.

• High Analytical Purity: Synthesized to a verified 99% HPLC purity, ensuring consistent results and molecular identity in sensitive biochemical assays.

• Stability-Focused Format: Arrives in a lyophilized (powder) form to maintain structural integrity and maximize stability during laboratory storage and handling.

• Specialized Molecular Mechanism: Offers a unique research pathway through its direct influence on actin-binding and polymerization cycles.

Technical Specifications

• Amino Acid Sequence: 43-amino acid sequence corresponding to Thymosin Beta-4

• Molecular Formula: C212_H350_N56_O78_S

• Molecular Weight: 4963 g/mol

• CAS Number: 77591-33-4

• Purity: 99% HPLC

• Research Notice: TB-500 is strictly for laboratory and scientific research use only. It is not approved for human or animal consumption, medical treatment, or therapeutic use.

Validated Synthesis & Expedited Fulfillment

Clinical-Grade Synthesis & Purity

Our RUO peptides are engineered via precision synthesis, following meticulously validated protocols to ensure batch-to-batch consistency and uncompromising accuracy. To maintain verified purity, every production lot undergoes independent analytical testing—including HPLC and mass spectrometry—to confirm molecular identity and a purity level of 99%. For expedited research timelines, we provide same-day fulfillment from our facility for orders placed before 12 PM PST.

References:

• Goldstein AL et al., Ann NY Acad Sci, 2007 1112:148–154

• Huff T et al., J Mol Biol, 2001 312(3):593–606

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Storage & Handling Guide

To ensure the long-term stability and reproducibility of your experimental results, please follow these standardized laboratory protocols for Thymosin Beta-4:

I. Long-Term Storage (Lyophilized Powder)

• Temperature: Store at -20°C for long-term stability. The lyophilized format is stable at room temperature for short-term transit but should be frozen upon arrival.

• Environment: Keep in a cool, dry place away from direct light. Ensure the vial remains tightly sealed to prevent moisture absorption (hygroscopy).

II. Reconstitution Protocol

• Solubility: DSIP is soluble in sterile water or bacteriostatic water.

III. Storage of Reconstituted Solution

• Short-Term: Once reconstituted, the solution should be stored at 2°C to 8°C and used within 7 days.

• Long-Term: For extended use, aliquot the solution into single-use volumes and store at -20°C or -80°C.

• Avoid Freeze-Thaw Cycles: Repeated freezing and thawing significantly degrade peptide structure. Always use fresh aliquots for each assay.

Research Use Only: This compound is intended for in vitro laboratory research and animal imaging studies. It is not for human or clinical use.