PT-141

PT-141

Melanocortin Receptor Agonist & Neuroendocrine Signaling Research Compound

Product Overview

PT-141, also known as Bremelanotide, is a synthetic peptide modeled after the naturally occurring melanocortin analog Melanotan II. In laboratory settings, it is utilized as a chemically defined tool to explore the activation of melanocortin receptors (specifically MC3R and MC4R) and their influence on the central nervous system. This peptide is highly regarded in preclinical research for its role in investigating neuroendocrine modulation, hypothalamic control mechanisms, and neuropeptide signaling pathways.

Key Research Applications

• GPCR Activation Modeling: Used in experimental workflows to study the selective binding and activation of G-protein coupled receptors, particularly the MC3 and MC4 isoforms.

• Neuroendocrine Signaling Research: Targeted in studies exploring how melanocortin agonists influence systemic physiological responses through central nervous system pathways.

• Behavioral Pharmacology Studies: Utilized to quantify the impact of hypothalamic signaling on motivated behaviors and physiological arousal in specialized animal models.

• Hypothalamic Pathway Modulation: Frequently employed to measure the peptide’s interaction with the neural circuits governing metabolic and autonomic functions.

• Neuronal Signaling Integration: Evaluated for its impact on signal transduction and the coordination of neurobiological responses in research environments.

Why Researchers Choose PT-141

• Selective Receptor Affinity: Exhibits targeted binding to MC3R and MC4R, providing a high-fidelity subject for studying specific melanocortin-mediated pathways.

• High Analytical Purity: Synthesized to a verified 99% HPLC purity, ensuring maximum accuracy and reproducibility in sensitive laboratory assays.

• Stability-Focused Format: Arrives in a lyophilized (powder) form to maintain structural integrity and maximize shelf life during laboratory handling.

• Verified Molecular Identity: Supported by comprehensive analytical data to ensure the chemical integrity required for peer-reviewed scientific investigation.

Technical Specifications

• Molecular Formula: C50_H68_N14_O10

• Molecular Weight: 1025.2 g/mol

• CAS Number: 189691-06-3

• Purity: 99% HPLC

• Research Notice: PT-141 is strictly for laboratory and scientific research use only. It is not approved for human or animal consumption, medical treatment, or therapeutic use.

---

Validated Synthesis & Expedited Fulfillment

Clinical-Grade Synthesis & Purity

Our RUO peptides are engineered via precision synthesis, following meticulously validated protocols to ensure batch-to-batch consistency and uncompromising accuracy. To maintain verified purity, every production lot undergoes independent analytical testing—including HPLC and mass spectrometry—to confirm molecular identity and a purity level of 99%. For expedited research timelines, we provide same-day fulfillment from our facility for orders placed before 12 PM PST.

References:

• Wessells H et al., J Urol, 2003 170(2 Pt 1):627–632

• Shadiack AM et al., J Sex Med, 2007 4(1):95–104

• Hadley ME, Ann NY Acad Sci, 2006 994:419–430

---

Storage & Handling Guide

To ensure the long-term stability and reproducibility of your experimental results, please follow these standardized laboratory protocols for PT-141:

I. Long-Term Storage (Lyophilized Powder)

• Temperature: Store at -20°C for long-term stability. The lyophilized format is stable at room temperature for short-term transit but should be frozen upon arrival.

• Environment: Keep in a cool, dry place away from direct light. Ensure the vial remains tightly sealed to prevent moisture absorption (hygroscopy).

II. Reconstitution Protocol

• Solubility: PT-141 is soluble in sterile water or bacteriostatic water. Gently swirl the vial; do not shake, as vigorous agitation can denature the peptide structure.

III. Storage of Reconstituted Solution

• Short-Term: Once reconstituted, the solution should be stored at 2°C to 8°C and used within 7 days.

• Long-Term: For extended use, aliquot the solution into single-use volumes and store at -20°C or -80°C.

• Avoid Freeze-Thaw Cycles: Repeated freezing and thawing significantly degrade peptide structure. Always use fresh aliquots for each assay.

Research Use Only: This compound is intended for in vitro laboratory research and animal imaging studies. It is not for human or clinical use.