THYMOSIN ALPHA-1

THYMOSIN ALPHA-1

Immune Modulating Peptide & T-Cell Homeostasis Research Compound

Product Overview

Thymosin Alpha-1 is a synthetic peptide fragment derived from prothymosin alpha, a protein naturally occurring in the thymus gland. In laboratory environments, it is utilized as a highly specialized tool for investigating the maturation and differentiation of T-lymphocytes. This 28-amino acid peptide is a cornerstone in preclinical research regarding the modulation of the adaptive immune response, specifically its role in enhancing MHC Class I expression and stimulating cytokine production.

Key Research Applications

• Immune System Modeling: Used in experimental workflows to study the maturation of progenitor T-cells into functional CD4+ and CD8+ subsets.

• Viral Replication Studies: Targeted in research exploring the peptide’s ability to inhibit viral transcription and improve the host cell’s defense mechanisms.

• Cytokine Regulation: Utilized to quantify the impact of TA1 on the production of signaling molecules such as Interferon-gamma (IFN-y) and Interleukin-2 (IL-2).

• Antitumor Research: Frequently employed to measure the peptide’s role in modulating natural killer (NK) cell activity and investigating its synergistic effects with chemotherapy in specialized models.

• Homeostatic Signaling: Evaluated for its impact on maintaining immune balance and preventing hyper-inflammatory responses in chronic disease simulations.

Why Researchers Choose Thymosin Alpha-1

• Targeted Immunomodulation: Offers a precise mechanism for investigating immune system upregulation without the systemic toxicity often associated with broader immunostimulants.

• High Analytical Purity: Synthesized to a verified 99% HPLC purity, ensuring maximum accuracy and reproducibility in sensitive laboratory environments.

• Stability-Focused Format: Arrives in a lyophilized (powder) form to maintain structural integrity and maximize shelf life during laboratory handling.

• Validated Biological Mimetic: Provides a consistent subject for investigating thymic hormones and their role in the endocrine-immune axis.

Technical Specifications

• Amino Acid Sequence: [Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH]

• Molecular Formula:  C129_H215_N33_O55

• Molecular Weight: 3108.3 g/mol

• CAS Number: 62304-98-7

• Purity: 99% HPLC

• Research Notice: Thymosin Alpha-1 is strictly for laboratory and scientific research use only. It is not approved for human or animal consumption, medical treatment, or therapeutic use.

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Validated Synthesis & Expedited Fulfillment

Clinical-Grade Synthesis & Purity

Our RUO peptides are engineered via precision synthesis, following meticulously validated protocols to ensure batch-to-batch consistency and uncompromising accuracy. To maintain verified purity, every production lot undergoes independent analytical testing—including HPLC and mass spectrometry—to confirm molecular identity and a purity level of 99%. For expedited research timelines, we provide same-day fulfillment from our facility for orders placed before 12 PM PST.

References:

• Teichman SL et al., J Clin Endocrinol Metab, 2006;91(3):799–805

• Jette L et al., Endocrinology, 2005;146(7):3052–3058

• Ionescu M et al., J Clin Endocrinol Metab, 2006;91(12):4792–4797

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Storage & Handling Guide

To ensure the long-term stability and reproducibility of your experimental results, please follow these standardized laboratory protocols for CJC-1295 with DAC:

I. Long-Term Storage (Lyophilized Powder)

• Temperature: Store at -20°C for long-term stability. The lyophilized format is stable at room temperature for short-term transit but should be frozen upon arrival.

• Environment: Keep in a cool, dry place away from direct light. Ensure the vial remains tightly sealed to prevent moisture absorption (hygroscopy).

II. Reconstitution Protocol

• Solubility: Allow peptide and water to come up to room temperature. CJC-1295 with DAC is soluble in sterile water or bacteriostatic water. Gently swirl the vial to dissolve the powder; do not shake, as agitation can damage the peptide structure.

III. Storage of Reconstituted Solution

• Short-Term: Once reconstituted, the solution should be stored at 2°C to 8°C and used within 7 days.

• Long-Term: For extended use, aliquot the solution into single-use volumes and store at -20°C or -80°C.

• Avoid Freeze-Thaw Cycles: Repeated freezing and thawing significantly degrade peptide structure. Always use fresh aliquots for each assay.

Research Use Only: This compound is intended for in vitro laboratory research and animal imaging studies. It is not for human or clinical use.