PE-22-28

PE-22-28

Neurotherapeutic & Potassium Channel Inhibitor Research Compound

Product Overview

PE-22-28 is a synthetic heptapeptide (7 amino acids) modeled after a shortened analog of spadin, derived from the propeptide released during the maturation of sortilin. In laboratory settings, it is utilized as a chemically defined tool to explore two-pore domain potassium channel (TREK-1) inhibition, neuroplasticity, and rapid-onset antidepressant-like signaling pathways. This peptide is highly regarded in preclinical research for its role in investigating neurogenesis and synaptic transmission under various experimental paradigms.

Key Research Applications

• TREK-1 Channel Inhibition: Used in experimental workflows to selectively block TREK-1 potassium channels, modulating neuronal membrane potential and excitability.

• Neuroplasticity & BDNF Regulation: Targeted in studies exploring the upregulation of brain-derived neurotrophic factor (BDNF) expression and dendritic spine formation.

• Molecular Neurogenesis Studies: Utilized to quantify cellular proliferation and neurogenic processes within hippocampal and prefrontal cortex models.

• Serotonergic Modulation: Frequently employed to measure the peptide’s interaction with monoamine neurotransmission and serotonergic signaling pathways.

• Stress Response Modeling: Evaluated for its impact on hypothalamic-pituitary-adrenal (HPA) axis regulation and cellular resilience under physiological stress conditions.

Why Researchers Choose PE-22-28

• Targeted Foundational Relevance: Derived from an endogenous propeptide framework, providing a high-fidelity subject for neuropharmacological research.

• High Analytical Purity: Synthesized to a verified 99% HPLC purity, ensuring maximum accuracy and reproducibility in sensitive laboratory assays.

• Stability-Focused Format: Arrives in a lyophilized (powder) form to maintain structural integrity and maximize shelf life during laboratory handling.

• Broad Investigative Scope: Demonstrates multifaceted interactions across central nervous system targets in preclinical paradigms.

Technical Specifications

• Amino Acid Sequence: Gly-Val-Ser-Trp-Gly-Leu-Arg

• Molecular Formula: C35H55N11O9

• Molecular Weight: 773.89 g/mol

• CAS Number: 1801959-12-5

• Purity: 99% HPLC

• Research Notice: PE-22-28 is strictly for laboratory and scientific research use only. It is not approved for human or animal consumption, medical treatment, or therapeutic use.

Validated Synthesis & Expedited Fulfillment

Clinical-Grade Synthesis & Purity

Our RUO peptides are engineered via precision synthesis, following meticulously validated protocols to ensure batch-to-batch consistency and uncompromising accuracy. To maintain verified purity, every production lot undergoes independent analytical testing—including HPLC and mass spectrometry—to confirm molecular identity and a purity level of 99%. For expedited research timelines, we provide same-day fulfillment from our facility for orders placed before 12 PM PST.

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Storage & Handling Guide

To ensure the long-term stability and reproducibility of your experimental results, please follow these standardized laboratory protocols for BPC-157:

I. Long-Term Storage (Lyophilized Powder)

• Temperature: Store at -20°C for long-term stability. The lyophilized format is stable at room temperature for short-term transit but should be frozen upon arrival.

• Environment: Keep in a cool, dry place away from direct light. Ensure the vial remains tightly sealed to prevent moisture absorption (hygroscopy).

II. Reconstitution Protocol

• Solubility: BPC-157 is soluble in sterile water or bacteriostatic water.

III. Storage of Reconstituted Solution

• Short-Term: Once reconstituted, the solution should be stored at 2°C to 8°C and used within 7 days.

• Long-Term: For extended use, aliquot the solution into single-use volumes and store at -20°C or -80°C.

• Avoid Freeze-Thaw Cycles: Repeated freezing and thawing significantly degrade peptide structure. Always use fresh aliquots for each assay.

Research Use Only: This compound is intended for in vitro laboratory research and animal imaging studies. It is not for human or clinical use.