KISSPEPTIN

KISSPEPTIN-10

G-Protein Coupled Receptor Agonist & Neuroendocrine Signaling Research Compound

Product Overview

Kisspeptin-10 is a synthetic decapeptide derived from the bioactive fragment of the KISS1 gene product. In preclinical research settings, it acts as a primary ligand for the GPR54 (KISS1R) receptor, triggering Gq-mediated signaling cascades that regulate the expression of gonadotropin-releasing hormone (GnRH). This peptide serves as a refined biochemical tool for investigating the intricate pathways of neuroendocrine signaling and reproductive physiology.

Key Research Applications

• Neuroendocrine Axis Mapping: Utilized to investigate the hormonal triggers that govern the hypothalamic-pituitary-gonadal (HPG) axis.

• GnRH Regulation Studies: Employed in experimental models to quantify the stimulation and pulsatile release of gonadotropin-releasing hormone.

• Puberty & Development Research: Targeted in studies exploring the genetic and molecular signals that initiate reproductive maturation.

• Signaling Cascade Analysis: Used to observe Gq-protein mediated pathways and intracellular calcium mobilization in specialized cell lines.

• Reproductive Peptide Profiling: Evaluated for its role in modulating the feedback loops between the brain and peripheral reproductive organs.

Why Researchers Choose Kisspeptin-10

• Targeted Receptor Affinity: Specifically engineered to bind and activate the KISS1R (GPR54) receptor with high potency.

• High Analytical Purity: Synthesized to a verified 99% HPLC purity, ensuring consistent molecular identity for sensitive laboratory assays.

• Lyophilized Stability: Provided in a stable, freeze-dried format to maintain structural integrity during long-term storage and handling.

• Validated Biological Activity: Modeled after the most active endogenous fragment to ensure reliable results in neuroendocrine signaling research.

Technical Specifications

• Amino Acid Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂

• Molecular Formula: C63_H78_N18_O13

• Molecular Weight: 1302.45 g/mol

• Purity: 99% HPLC

• Research Notice: Kisspeptin-10 is strictly for laboratory and scientific research use only. It is not approved for human or animal consumption, medical treatment, or therapeutic use.

Validated Synthesis & Expedited Fulfillment

Clinical-Grade Synthesis & Purity

Our RUO peptides are engineered via precision synthesis, following meticulously validated protocols to ensure batch-to-batch consistency and uncompromising accuracy. To maintain verified purity, every production lot undergoes independent analytical testing—including HPLC and mass spectrometry—to confirm molecular identity and a purity level of 99%. For expedited research timelines, we provide same-day fulfillment from our facility for orders placed before 12 PM PST.

References:

1. Kotani M et al., J Biol Chem, 2001 276(37):34631–34636

2. Oakley AE et al., Endocr Rev, 2009 30(6):713–743

3. de Roux N et al., N Engl J Med, 2003 349(17):1614–1627