DSIP

DSIP (Delta Sleep-Inducing Peptide)

Neuroendocrine & Circadian Rhythm Research Compound

Product Overview

DSIP (Delta Sleep-Inducing Peptide) is a synthetic neuropeptide composed of nine amino acids (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu). Primarily recognized for its role in sleep-related signaling, it is an essential tool in laboratory environments for investigating neuroendocrine regulation and physiological stress adaptation. By interacting with GABAergic and hypothalamic pathways, DSIP provides a specialized framework for studying the molecular drivers of circadian biology.

Key Research Applications

• Circadian Rhythm Analysis: Utilized to explore the peptide-level regulation of sleep-wake cycles and delta-wave induction.

• Neuroendocrine Pathway Mapping: Targeted in research measuring the modulation of hypothalamic and pituitary hormone release.

• Stress Adaptation Modeling: Used to assess biological responses to environmental stressors and the maintenance of systemic homeostasis.

• GABAergic Signaling Studies: Frequently employed to quantify interactions between neuropeptides and inhibitory neurotransmitter systems.

• Sleep Architecture Research: Evaluated in preclinical models to identify the biochemical markers associated with deep-stage sleep.

Why Researchers Choose DSIP (Delta Sleep-Inducing Peptide)

• Mechanistic Versatility: Functions as a complex neuromodulator across both central and peripheral endocrine systems.

• High Analytical Purity: Synthesized to a verified 99% HPLC purity, ensuring high-fidelity data and reproducibility in sensitive assays.

• Lyophilized Stability: Arrives in a stable, freeze-dried powder format to preserve structural integrity during laboratory storage and reconstitution.

• Defined Molecular Profile: Offers a precise, chemically defined subject for structural biology and peptide neurobiology experiments.

Technical Specifications

• Amino Acid Sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu

• Molecular Formula: C35_H48_N10_O15

• Molecular Weight: 848.8 g/mol

• CAS Number: 62568-57-4

• Purity: 99% HPLC

• Research Notice: DSIP is strictly for laboratory and scientific research use only. It is not approved for human or animal consumption, medical treatment, or therapeutic use.

Validated Synthesis & Expedited Fulfillment

Clinical-Grade Synthesis & Purity

Our RUO peptides are engineered via precision synthesis, following meticulously validated protocols to ensure batch-to-batch consistency and uncompromising accuracy. To maintain verified purity, every production lot undergoes independent analytical testing—including HPLC and mass spectrometry—to confirm molecular identity and a purity level of 99%. For expedited research timelines, we provide same-day fulfillment from our facility for orders placed before 12 PM PST.

References:

• Schoenenberger GA et al., Proc Natl Acad Sci USA, 1977 74(9):4025–4029

• Graf MV et al., Neuropeptides, 1984 4(3):225–238

• Antonijevic I et al., J Neuroendocrinol, 1992 4(4):431–439

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Storage & Handling Guide

To ensure the long-term stability and reproducibility of your experimental results, please follow these standardized laboratory protocols for DSIP:

I. Long-Term Storage (Lyophilized Powder)

• Temperature: Store at -20°C for long-term stability. The lyophilized format is stable at room temperature for short-term transit but should be frozen upon arrival.

• Environment: Keep in a cool, dry place away from direct light. Ensure the vial remains tightly sealed to prevent moisture absorption (hygroscopy).

II. Reconstitution Protocol

• Solubility: DSIP is soluble in sterile water or bacteriostatic water.

• Procedure: Gently add the diluent to the vial. Do not shake the vial vigorously, as this can cause protein denaturation or mechanical shear of the peptide chain. Instead, swirl the vial gently until the powder is fully dissolved.

III. Storage of Reconstituted Solution

• Short-Term: Once reconstituted, the solution should be stored at 2°C to 8°C and used within 7 days.

• Long-Term: For extended use, aliquot the solution into single-use volumes and store at -20°C or -80°C.

• Avoid Freeze-Thaw Cycles: Repeated freezing and thawing significantly degrade peptide structure. Always use fresh aliquots for each assay.

Research Use Only: This compound is intended for in vitro laboratory research and animal imaging studies. It is not for human or clinical use.