EPITHALON

EPITHALON (Epitalon)

Telomerase Activator & Genomic Stability Research Compound

Product Overview

Epithalon (Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) modeled after Epithalamin, a natural peptide produced in the thymus. In laboratory settings, it is utilized as a chemically defined tool to investigate the modulation of pineal signaling pathways, specifically regarding their impact on circadian gene expression and oxidative regulation. This peptide is frequently evaluated in preclinical models for its role in telomerase activation and its broader implications for epigenetic control and neuroendocrine regulation.

Key Research Applications

• Genomic Stability Modeling: Used in experimental workflows to study the mechanisms of telomerase activation and telomere maintenance.

• Circadian Rhythm Research: Targeted in studies exploring the regulation of circadian genes via pineal peptide signaling.

• Oxidative Stress Studies: Utilized to quantify cellular responses to oxidative damage and the modulation of antioxidant pathways.

• Epigenetic Regulation: Frequently employed to measure changes in gene expression and transcriptional control within neuroendocrine systems.

• Aging & Longevity Assays: Evaluated in preclinical models to examine the relationship between peptide signaling and cellular senescence markers.

Why Researchers Choose Epithalon (Epitalon)

• Mechanistic Specificity: Acts as a potent modulator of telomerase activity and pineal gland function in controlled environments.

• High Analytical Purity: Synthesized to a verified 99% HPLC purity, ensuring maximum accuracy and reproducibility for sensitive biochemical assays.

• Stability-Focused Format: Arrives in a lyophilized (powder) form to maintain structural integrity and maximize shelf life during laboratory handling.

• Derived Biological Relevance: Based on the structure of natural Epithalamin, providing a precise subject for structure-activity relationship research.

Technical Specifications

• Amino Acid Sequence: Ala-Glu-Asp-Gly

• Molecular Formula: C14​_H22_​N4_​O9​

• Molecular Weight: 390.35 g/mol

• CAS Number: 307297-39-8

• Purity: 99% HPLC

• Research Notice: Epithalon is strictly for laboratory and scientific research use only. It is not approved for human or animal consumption, medical treatment, or therapeutic use.

Validated Synthesis & Expedited Fulfillment

Clinical-Grade Synthesis & Purity

Our RUO peptides are engineered via precision synthesis, following meticulously validated protocols to ensure batch-to-batch consistency and uncompromising accuracy. To maintain verified purity, every production lot undergoes independent analytical testing—including HPLC and mass spectrometry—to confirm molecular identity and a purity level of 99%. For expedited research timelines, we provide same-day fulfillment from our facility for orders placed before 12 PM PST.

References:

• Khavinson VK et al., Bull Exp Biol Med, 2003;135(4):429–432

• Khavinson VK et al., Biogerontology, 2007;8(3):305–313

• Anisimov VN et al., Neuro Endocrinol Lett, 2003;24(3–4):233–240

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Storage & Handling Guide

To ensure the long-term stability and reproducibility of your experimental results, please follow these standardized laboratory protocols for Epithalon:

I. Long-Term Storage (Lyophilized Powder)

• Temperature: Store at -20°C for long-term stability. The lyophilized format is stable at room temperature for short-term transit but should be frozen upon arrival.

• Environment: Keep in a cool, dry place away from direct light. Ensure the vial remains tightly sealed to prevent moisture absorption (hygroscopy).

II. Reconstitution Protocol

• Solubility: DSIP is soluble in sterile water or bacteriostatic water.

III. Storage of Reconstituted Solution

• Short-Term: Once reconstituted, the solution should be stored at 2°C to 8°C and used within 7 days.

• Long-Term: For extended use, aliquot the solution into single-use volumes and store at -20°C or -80°C.

• Avoid Freeze-Thaw Cycles: Repeated freezing and thawing significantly degrade peptide structure. Always use fresh aliquots for each assay.

Research Use Only: This compound is intended for in vitro laboratory research and animal imaging studies. It is not for human or clinical use.